The Warriors Path becomes The Great Wagon Road

In the 18th-century migrations, few trails in America were more important than the Indian route which ran east of the Appalachians from Pennsylvania to Georgia. This Ancient Warriors Path had long been used by Iroquois tribesmen of the north to travel south and trade or make war in Virginia and the Carolinas. By a series of treaties with the powerful Five Nations of the Iroquois, the English acquired use of the Warriors Path. After 1744 they took over the land itself. The growth of the route into the principal highway of the colonial backcountry was important in the development of the nation. Over this road came English, Scots-Irish, and German settlers to claim land. The Warriors Path led from the Iroquois Confederacy around the Great Lakes through what later became Lancaster County, Pennsylvania, to Bethlehem, York, and Gettysburg, into western Maryland around what is now Hagerstown, across the Potomac River at Evan Watkins Ferry, following the narrow path across the "back country" (or "up country" or "Piedmont") to Winchester, Virginia, through the Shenandoah Valley, to Harrisburg, Staunton, Lexington, and Roanoke, to Salem, North Carolina, to Salisbury, where it was joined by the east–west Catawba and Cherokee Trading Path at the Trading Ford across the Yadkin River in Rowan County, to Charlotte, then to Rock Hill, South Carolina, where it branches into two routes to Augusta and Savannah, Georgia.

(Source: The Scots-Irish From Ulster and The Great Philadelphia Wagon Road, by Brenda E. McPherson Compton, http://www.electricscotland.com/history/america/wagon_road.htm)

The Paxton Boys

(click image to enlarge)

The 1763 uprising of the "Paxton Boys" was triggered by the Quaker government's perceived indifference to Indian attacks on the Pennsylvania frontier, and by the western district's underrepresentation in the colonial assembly.
The Paxton Boys were Scots-Irish Presbyterian farmers from the area near Paxton Church, Paxtang, who formed a vigilante group in response to the Indian uprising known as Pontiac's Rebellion. The Paxton Boys felt that the government of colonial Pennsylvania was negligent in providing them with protection, and so decided to take matters into their own hands.
As the nearest belligerent Indians were some 200 miles west of Paxton, the men turned their anger towards the local Conestoga (or Susquehannock) Indians—many of them Christians—who lived peacefully in small enclaves in the midst of white Pennsylvania settlements. (The Paxton Boys believed or claimed to believe that these Indians secretly provided aid and intelligence to the hostile Indians.) On December 14, 1763 a group of more than fifty Paxton Boys marched on an Indian village near Millersville, Pennsylvania, murdered the six Indians they found there, and burned the bloody cabin in which the killings were done. Later, colonists looking through the ashes of the cabin, found a bag containing the Conestoga's 1701 treaty signed by William Penn, which pledged that the colonists and the Indians "shall forever hereafter be as one Head & One Heart, & live in true Friendship & Amity as one People."
The remaining fourteen Susquehannocks were placed in protective custody by Governor John Penn in Lancaster. But on December 27, Paxton Boys broke into the workhouse at Lancaster and brutally killed and mutilated all fourteen. These two actions, which resulted in the deaths of all but two of the last of the Susquehannocks, are sometimes known as the "Conestoga Massacre." The Governor issued bounties for the arrest of the murderers, but no one came forward to identify them.

"The German Bleeds..," never the Quaker

political cartoon, circulated after the 1763 Conestoga massacre
(click image to enlarge)

"The German bleeds & bears ye Furs
Of Quaker Lords & Savage Airs

The Hibernian frets with new Disaster
And kicks to fling his broad brim'd Master

But help at hand Resolves to hold down
The Hibernian's head or tumble all down"
In 1760s backcountry Pennsylvania Scots-Irish and German settlers became increasingly convinced that Quaker leaders were encouraging and arming neighboring Indians to brutally attack their families in an effort to make them leave the colony altogether. In 1763 their resentment erupted into violence when the Scots-Irish "Paxton Boys" murdered six Indians at the Conestoga town near Lancaster, and afterward burned their cabins. Subsequent attacks followed in an attempt to wipe out their entire local tribe. The gang threatened to march eastward to Philadelphia killing all Indians in their path. In the image above, one of Pennsylvania's first political cartoons, an Indian and Quaker ride on the backs of German and Scots-Irish settlers as a house in the background is burning. A mother and child lie dead in the foreground. It is true that Quakers provided arms to some frontier Indians. More significantly, upon disembarking at the port of Philadelphia, German and Scots-Irish immigrants were maneuvered by the Quaker authorities into settling the western Pennsylvania frontier. Their presence there provided a strategic defense shield between the gentrified coast and hostile Indian nations, without having to compromise their personal Quaker pacifist principles. 

David James Dove, re: The Paxton Boys

From The Quaker Unmask'd, or, Plain Truth, by David James Dove, Philadelphia: Andrew Steuart, 1764:

WHEN the Indian Incursions last Summer laid waste a considerable Part of our Frontier, by which near a thousand Families were drove from their Places, reduced to the utmost Poverty, and thrown upon the Public-Charity for the Support of their miserable Lives.—How did these meek, merciful, compassionate Quakers (who would seem to monopolize Christian Charity, and all the Tenderness of human Nature amongst themselves) behave on so melancholy an Occasion?–To their immortal Infamy be it known, that when every other religious Society in the City, even the Roman-Catholicks, whom they so much despise, (tho' saddled at the Time with the heavy Expence of building a Chapel) were sensibly affected with the Distresses of the poor unhappy Sufferers, and promoted very generous and liberal Contributions for their Relief and Support. These compassionate and merciful Christians [the Quakers], so easily affected with Pity for Indians, would not grant a single Farthing (as a Society) for the Relief of their Fellow Subjects. Tho' Justice requires we should exempt from this Odium a few worthy Individuals in the City, who contributed on the Occasion; as also a few others in the Town and Neighbourhood of Lancaster, who raised about Thirty Pounds for the same Purpose.

WHEREAS when their Good Brethern the Indians (some of whom were well known by Officers now in the City, to have been in the Battle against Col. BOUQUET, and others at the Siege of Fort Pitt, during the Summer) seem'd to be in Danger of receiving their just Deserts from the Hands of a bereft and injured People, no Toils or Fatigues by Night or Day are thought too great, nor no Expence too much to protect those Bosom Friends. Nay, their very fundamental Principles of Non-Resistance, which would never before bend in Defence of King or Country, are cheerfully sacrificed on the interesting Occasion, as a Compliment to perfidious Savages.

THE PAXTON PEOPLE'S coming down armed, in a seemingly hostile Manner, is also justly to be condemned,—But whilst we condemn particular Facts, let us not misrepresent the general Characters of these People.

Let it be considered, that they had, long before, sent several Petitions to the Governor and Assembly, which, its suppos'd, have been conceal'd by some ill designing persons: And tho' his Honour never receiv'd these Remonstances, yet the distress'd People believ'd he had, and look'd upon themselves as utterly neglected, and their sufferings despis'd by the Government. . .

WHAT these People intended by their coming down arm'd let themselves declare. I only observe, that the Manner of their Behavior when they came, did them Honour; as it shew'd them to be brave, loyal and discreet.

Benjamin Franklin, re: The Conestoga Massacre

From A Narrative of the Late Massacres, in Lancaster County, of a Number of Indians, Friends of this Province, By Persons Unknown. With some Observations on the same, by Benjamin Franklin, Philadelphia, 1764:

On Wednesday, the 14th of December, 1763, Fifty-seven Men, from some of our Frontier Townships, who had projected the Destruction of this little Common-wealth [Conestoga], came, all well-mounted, and armed with Firelocks, Hangers and Hatchets, having traveled through the Country in the Night, to Conestogoe Manor. There they surrounded the small Village of Indian Huts, and just at Break of Day broke into them all at once. Only three Men, two Women, and a young Boy, were found at home, the rest being out among the neighbouring White People, some to sell the Baskets, Brooms and Bowls they manufactured, and others on other Occasions. These poor defenceless Creatures were immediately fired upon, stabbed and hatcheted to Death! The good Shehaes [a Conestoga] among the rest, cut to Pieces in his Bed. All of them were scalped, and otherwise horribly mangled. Then their Huts were set on Fire, and most of them burnt down. When the Troop, pleased with their own Conduct and Bravery, but enraged that any of the poor Indians had escaped the Massacre, rode off, and in small Parties, by different Roads, went home.

The universal Concern of the neighbouring White People on hearing of this Event, and the Lamentations of the younger Indians, when they returned and saw the Desolation, and the butchered half-burnt Bodies of their murdered Parents, and other Relations, cannot well be expressed.

The Magistrates of Lancaster sent out to collect the remaining Indians, brought them into the Town for their better Security against any further Attempt, and it is said condoled with them on the Misfortune that had happened, took them by the Hand, comforted and promised them Protection. They were all put into the Workhouse, a strong Building, as the Place of greatest Safety. . .

. . . those cruel Men again assembled themselves, and hearing that the remaining fourteen Indians were in the Work-House at Lancaster, they suddenly appeared in that Town, on the 27th of December. Fifty of them, armed as before, dismounting, went directly to the Work-House, and by Violence broke open the Door, and entered with the utmost Fury in their Countenances. When the poor Wretches saw they had no Protection nigh, nor could possibly escape, and being without the least Weapon for Defence, they divided into their little Families, the Children clinging to the Parents; they fell on their Knees, protested their Innocence, declared their Love to the English, and that, in their whole Lives, they had never done them Injury; and in this Posture they all received the Hatchet! Men, Women and little Children–were every one inhumanly murdered! – in cold Blood!

The barbarous Men who committed the atrocious act, in Defiance of Government, of all Laws human and divine, and to the eternal Disgrace of their Country and Colour, then mounted their Horses, huzza'd in Triumph, as if they had gained a Victory, and rode off – unmolested!

The Bodies of the Murdered were then brought out and exposed in the Street, till a Hole could be made in the Earth, to receive and cover them.

But the Wickedness cannot be covered, the Guilt will lie on the whole Land, till Justice is done on the Murderers. THE BLOOD OF THE INNOCENT WILL CRY TO HEAVEN FOR VENGEANCE.

John Harris to Owen Biddle, 1776

Paxton, July 29th, 1776. 

Sir,

I was informed by two men that came here last week from Sunbury for some Gun Powder stored with me for No. Thumberland Coty, that Two Seneca Indians came to the Great Island on the West Branch of Susquehannah ab't Two Weeks agoe, & that the next day after sd Indians arrived, the Indians in that neighbourhood moved off with their Familys, Effects, &c., & cut down some if not the whole of their Indian Corn; it appears as if they designed to Join the Canada Indians, or such of the Six Nations or other Indian Nations that may chuse to take an active part in the present warr ag't us; the English Officers that made their escape from Lebanon in Lancaster Coty, no doubt did perswade the Indians on their tour up this River, to take up the Hatchet ag't us, You may depend on it that the Indians cannot be kept Neuter, no Treaty or Presents can Prevent their being concern'd in the warr, therefore if a number of their warriors were engaged in our service, it might perhaps, (if not now too late) prevent them Destroying ourselves, our late success in Carolina may encourage the Southern Indians to join us in that quarter, If timely apply'd to, they would be of the greatest service for to assist us to cut off the Northern or Western Ind's, If a general Indian warr shoud Happen, (may God forbid) that an Indian Warr shoud take place, but we ought to use all the means in our power to prevent it ag't ourselves, & if there is now no preventing it, Let the Warr be pushed on with the Greatest Vigour into their own Country, (they Begining first) Surely their Territory of the best lands in America is a fine prize for our Warriors to fight for; the Frontier Co'tys in this Province is in a Deplorable Situation for want of Powder & lead shoud the Indians Break out soon, w'ch I assure you 
is expected, the present Q'tys of ammunition in sd Co'tys is verry Trifling, proper magazines at Posts of Amunition & provisions ought to be laid up in time for the Publick use (If Wanted) before escorts & a Treble Expence in conveying sd necessary articles to proper places might be expedient. I know the Indians well from my infancy, warr is their delight, & they will be concern'd on some side & 
Likely both for & ag't us; the Greatest Spirit Imaginable Reigns among us, I hope it may continue to the end of the Present unjust & cruel warr undertaken by Great Brittain against us, it's Quite Right now, for the Hon'ble the Continental Congress to Get all the Foreign aid Judg'd necessary to assist us, a good Fleet especially, superior with our assistance to that of our Enemy's, with Engineers, &c., from my love for my bleeding country, my acquaintance with yr self, knowing yr situation & Influence, is the Reason I make free to write you this long Incorrect Epistle; there is two places in this county I have found by Enquiry that it's Likely Good flints may be made. If you'll please to write me a Letter Informing me any news, you'll please to communicate [through] Lancaster post or first safe conveyance shall take it as a favor. I am Sir,
with the 
Greatest Respect, your most obed't, 

& most Humble Servant,
JOHN HARRIS.

Directed, 

To Owen Biddle, Esquire, in Philadelphia

Harris' Ferry, Pennsylvania

From the Dauphin County, Pennsylvania website:

John Harris (1673-1748), a native of Yorkshire, England, arrived in Philadelphia as one of the first emigrants to accompany William Penn. In approximately 1719, Harris moved with his wife Esther from Chester County to Lancaster County. They then eventually built a log cabin on the banks of the Susquehanna, near the present juncture of Paxton and Front streets.

In about 1727, John Harris, Jr. was born. Harris, Jr. became the founder of Harrisburg and the leader in the movement to establish Dauphin County. Other settlers soon followed in the footsteps of John Harris, Sr., and on December 17, 1733, the proprietaries of Pennsylvania granted to him by patent, 300 acres of land, within which was included the present site of the Dauphin County Court House. He developed a large trade with the Indians in fur and skins and established numerous trading posts. He also began farming on a small scale and introduced the first plow to the vicinity. Harris, Sr. established the first ferry across the Susquehanna, which in time became so popular that that place was no longer called by its Indian name of Peixtan, but Harris' Ferry.

John Harris, Sr. died in 1748, and was buried, at his request, beneath the shade of a mulberry tree in River Park below Harrisburg Hospital. He had once been tied to this tree by hostile Indians who were prepared to burn him, but fortuitously, his Indian friends rescued him in the nick of time. John Harris, Jr. operated the ferry established by his father, over which were taken many boatloads of supplies for the Continental army west of the Susquehanna River.