The Warriors Path becomes The Great Wagon Road

In the 18th-century migrations, few trails in America were more important than the Indian route which ran east of the Appalachians from Pennsylvania to Georgia. This Ancient Warriors Path had long been used by Iroquois tribesmen of the north to travel south and trade or make war in Virginia and the Carolinas. By a series of treaties with the powerful Five Nations of the Iroquois, the English acquired use of the Warriors Path. After 1744 they took over the land itself. The growth of the route into the principal highway of the colonial backcountry was important in the development of the nation. Over this road came English, Scots-Irish, and German settlers to claim land. The Warriors Path led from the Iroquois Confederacy around the Great Lakes through what later became Lancaster County, Pennsylvania, to Bethlehem, York, and Gettysburg, into western Maryland around what is now Hagerstown, across the Potomac River at Evan Watkins Ferry, following the narrow path across the "back country" (or "up country" or "Piedmont") to Winchester, Virginia, through the Shenandoah Valley, to Harrisburg, Staunton, Lexington, and Roanoke, to Salem, North Carolina, to Salisbury, where it was joined by the east–west Catawba and Cherokee Trading Path at the Trading Ford across the Yadkin River in Rowan County, to Charlotte, then to Rock Hill, South Carolina, where it branches into two routes to Augusta and Savannah, Georgia.

(Source: The Scots-Irish From Ulster and The Great Philadelphia Wagon Road, by Brenda E. McPherson Compton, http://www.electricscotland.com/history/america/wagon_road.htm)

"Gone to Carolina"

It is probable that some families left Virginia due to increasing conflict between settlers and Indians. In 1755 attacks by the Shawnee along the frontier increased significantly. In October 1755 Colonel Adam Stephen, one of George Washington's officers, wrote from Winchester, Virginia that the Indians "... go about and Commit their Outrages at all hours of the Day and nothing is to be seen or heard of, but Desolation and murder heightened with all Barbarous Circumstances and unheard of Instances of Cruelty.... The Smoke of the Burning Plantations darken the day, and hide the neighboring mountains from our sight...".
These events were part of the struggle now known as the French and Indian War. During this struggle England and France strove for control of the lands west of the Alleghenies between New Orleans and Quebec. In order to forestall French intent, Governor Dinwiddie of Virginia sent a military expedition under General Edward Braddock to the Valley of the Ohio. Braddock and his men, however, were ambushed as they moved into the Ohio Valley; Braddock was killed, and only a few of his men (including George Washington) survived to make their way back to Virginia. This defeat left frontier settlements in the Shenandoah Valley virtually defenseless, and set off a panic among settlers. Many of the settlers fled to North Carolina at this time. County records of this period frequently identify settlers with the phrase "gone to Carolina."