The Paxton Boys

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The 1763 uprising of the "Paxton Boys" was triggered by the Quaker government's perceived indifference to Indian attacks on the Pennsylvania frontier, and by the western district's underrepresentation in the colonial assembly.
The Paxton Boys were Scots-Irish Presbyterian farmers from the area near Paxton Church, Paxtang, who formed a vigilante group in response to the Indian uprising known as Pontiac's Rebellion. The Paxton Boys felt that the government of colonial Pennsylvania was negligent in providing them with protection, and so decided to take matters into their own hands.
As the nearest belligerent Indians were some 200 miles west of Paxton, the men turned their anger towards the local Conestoga (or Susquehannock) Indians—many of them Christians—who lived peacefully in small enclaves in the midst of white Pennsylvania settlements. (The Paxton Boys believed or claimed to believe that these Indians secretly provided aid and intelligence to the hostile Indians.) On December 14, 1763 a group of more than fifty Paxton Boys marched on an Indian village near Millersville, Pennsylvania, murdered the six Indians they found there, and burned the bloody cabin in which the killings were done. Later, colonists looking through the ashes of the cabin, found a bag containing the Conestoga's 1701 treaty signed by William Penn, which pledged that the colonists and the Indians "shall forever hereafter be as one Head & One Heart, & live in true Friendship & Amity as one People."
The remaining fourteen Susquehannocks were placed in protective custody by Governor John Penn in Lancaster. But on December 27, Paxton Boys broke into the workhouse at Lancaster and brutally killed and mutilated all fourteen. These two actions, which resulted in the deaths of all but two of the last of the Susquehannocks, are sometimes known as the "Conestoga Massacre." The Governor issued bounties for the arrest of the murderers, but no one came forward to identify them.

Harris' Ferry, Pennsylvania

From the Dauphin County, Pennsylvania website:

John Harris (1673-1748), a native of Yorkshire, England, arrived in Philadelphia as one of the first emigrants to accompany William Penn. In approximately 1719, Harris moved with his wife Esther from Chester County to Lancaster County. They then eventually built a log cabin on the banks of the Susquehanna, near the present juncture of Paxton and Front streets.

In about 1727, John Harris, Jr. was born. Harris, Jr. became the founder of Harrisburg and the leader in the movement to establish Dauphin County. Other settlers soon followed in the footsteps of John Harris, Sr., and on December 17, 1733, the proprietaries of Pennsylvania granted to him by patent, 300 acres of land, within which was included the present site of the Dauphin County Court House. He developed a large trade with the Indians in fur and skins and established numerous trading posts. He also began farming on a small scale and introduced the first plow to the vicinity. Harris, Sr. established the first ferry across the Susquehanna, which in time became so popular that that place was no longer called by its Indian name of Peixtan, but Harris' Ferry.

John Harris, Sr. died in 1748, and was buried, at his request, beneath the shade of a mulberry tree in River Park below Harrisburg Hospital. He had once been tied to this tree by hostile Indians who were prepared to burn him, but fortuitously, his Indian friends rescued him in the nick of time. John Harris, Jr. operated the ferry established by his father, over which were taken many boatloads of supplies for the Continental army west of the Susquehanna River.